Muscle growth

In this subproject, structural and mechanical changes of muscle tissue during growth will be recorded. The goal of the research project is the development and validation of a growth model for skeletal muscle, which will be achieved by a close integration between experiment and modeling. Knowledge of the structural changes (e.g. 3D muscle fiber architecture, see Fig.) is an essential prerequisite for a deeper understanding of the differentiation of muscle shape during growth. This not only advances the fundamental understanding of locomotion at different ages, but can furthermore find application in the field of movement and exercise science, medical technology, robotics and prosthetics.

Literature:

• Walter, F., Seydewitz, R., Mitterbach, P., Siebert, T., Böl, M., 2022. On a three-dimensional model for the description of the passive characteristics of skeletal muscle tissue. Biomech Model Mechanobiol. [link]
• Papenkort, S., Böl, M., Siebert, T., 2021. Architectural model for muscle growth during maturation. Biomech Model Mechanobiol 20, 2031-2044. [Link]
• Leichsenring, K., Viswanathan, A., Kutschke, S., Siebert, T., Bol, M., 2021. Age-dependent mechanical and microstructural properties of the rabbit soleus muscle. Acta Biomater 134, 453-465. [Link]
• Papenkort, S., Böl, M., Siebert, T., 2020. Three-dimensional architecture of rabbit M. soleus during growth. J Biomech 112, 110054. doi.org.10.1016 [Link]
• Siebert T, Tomalka A, Stutzig N, Leichsenring K, Böl M (2017) Changes in three-dimensional muscle structure of rabbit gastrocnemius, flexor digitorum longus, and tibialis anterior during growth. J Mech Behav Biomed Mater (in press) [link]
• Böl, M., Leichsenring, K., Siebert, T., 2017. Effects of Growth on Muscle, Tendon, and Aponeurosis Tissues in Rabbit Shank Musculature. Anat Rec (Hoboken) 300, 1123-1136. [link]